Publications
 
 

Publications

Journal Publications
*corresponding   To request for articles, please email or go to Researchgate

H-index and citations

2016
  • Zhang S, Chu WC, Lai RC, Lim SK, Hui JH, Toh WS* (2016) Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration. Osteoarthritis and Cartilage (In press)

  • Toh WS*, Brittberg M, Farr J, Foldager CB, Gomoll AH, Hui JH, Richardson JB, Roberts S, Spector M (2016) Cellular senescence in aging and osteoarthritis: Implications for cartilage repair. Acta Orthopaedica (In press)

  • Foldager CB, Bendtsen M, Berg LC, Brinchmann JE, Brittberg M, Bunger C, Canesco J, Chen L, Christensen BB, Colombier P, Deleuran BW, Edwards J, Elmengaard B, Farr J, Gatenholm B, Gomoll AH, Hui JH, Jakobsen RB, Jørgensen NL, Kassem M, Koch T, Kold S, Krogsgaard MR, Lauridsen H, Le D, Le Visage C, Lind M, Nygaard JV, Olesen ML, Pedersen M, Rathcke M, Richardson JB, Roberts S, Rölfing JH, Sakai D, Toh WS, Urban J, Spector M (2016) Regeneration in the Ageing Population, 1st Aarhus Regenerative Orthopedics Symposium (AROS) Supplement. Acta Orthopaedica (In press)

  • Lim SM, Yap AU, Loo CS, Ng J, Goh CY, Hong CH, Toh WS* (2016) Comparison of cytotoxicity test models for evaluating resin-based composites. Human and Experimental Toxicology (In press)

  • Yap AU, Pandya M, Toh WS* (2016) Depth of cure of contemporary bulk-fill resin-based composites.
    Dental Materials Journal 35(3): 503-510. link
  • Zhang S, Lu Q, Cao T, Toh WS* (2016) Adipose tissue and extracellular matrix development by injectable decellularized adipose matrix loaded with basic fibroblast growth factor. Plastic and Reconstructive Surgery
    137(4): 1171-1180. link

  • Movahednia MM, Kidwai FK, Jokhun DS, Squier CA, Toh WS, Cao T (2016) Potential applications of keratinocytes derived from human embryonic stem cells. Biotechnology Journal 11(1): 58-70. link

  • Foldager CB, Toh WS, Christensen BB, Lind M, Gomoll AH, Spector M (2016) Collagen type IV and laminin expressions during cartilage repair and in late clinically failed repair tissues from human subjects. Cartilage
    7(1): 52-61. link
2015
  • Zhang S, Yap AU, Toh WS* (2015) Stem cells for temporomandibular joint repair and regeneration. Stem Cell Reviews and Reports 11(5): 728-742  link

  • Toh WS*, Foldager CB, Hui JH, Olsen BR, Spector M (2015) Exploiting stem cell-extracellular matrix interactions for cartilage regeneration – A focus on basement membrane molecules. Current Stem Cell Research and Therapy Special issue: "New approaches in stem cell technology and innovative biomaterials for tissue engineering and regenerative medicine” (Invited; In press) link

  • Toh WS*, Yap AU, Lim SY (2015) In vitro biocompatibility of contemporary bulk-fill composites.
    Operative Dentistry 40(6): 644-652. link

  • Liu H, Toh WS, Ng KW, Sant S, Salgado A, Zhang Z (2015) Stem Cells: Microenvironment, Micro/Nanotechnology and Application. Stem Cells International 2015: 398510 (Invited Editorial) link

  • Lu Q, Pandya M, Rufaihah AJ, Rosa V, Tong HJ, Seliktar D, Toh WS* (2015) Modulation of dental pulp stem cell odontogenesis in a tunable PEG-fibrinogen hydrogel system. Stem Cells International 2015: 525367 link
    Special Issue: “Stem Cells: Microenvironment, Micro/Nanotechnology and Application”

  • Movahednia MM, Kidwai FK, Zou Y, Tong HJ, Liu X, Islam I, Toh WS, Raghunath M, Cao T (2015) Differential effects of extracellular microenvironment on human embryonic stem cells differentiation into keratinocytes and their subsequent replicative lifespan. Tissue Engineering Part A 21(7-8): 1432-1443.  link

  • Cherbuin T, Movahednia MM, Toh WS*, Cao T* (2015) Investigation of human embryonic stem cell-derived keratinocytes as an in vitro research model for dynamic mechanical stress response. Stem Cell Reviews and Reports 11(3): 460-473 link
2014
  • Toh WS* (2014) Recent progress in stem cell chondrogenesis. Progress in Stem Cell 1(1): 7-17 link

  • Toh WS*, Foldager CB, Pei M, Hui JH (2014) Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration. Stem Cell Reviews and Reports 10(5): 686-696 link

  • Toh WS* (2014) Injectable hydrogels in dentistry: advances and promises. Austin Journal of Dentistry 1(1): 2 (Editorial)

  • Toh WS*, Loh XJ* (2014) Advances in hydrogel delivery systems for tissue regeneration. Materials Science and Engineering C 45:690-697 link Special issue: “Emerging Biofunctional Materials”

  • Rosa V, Toh WS, Cao T, Shim W (2014) Inducing pluripotency for disease modeling, drug development and craniofacial applications. Expert Opinion on Biological Therapy 14(9): 1233-1240 link

  • Li Y, Kandasamy K, Chuah JKC, Lam YN, Toh WS, Oo ZY, Zink D (2014) Identification of nephrotoxic compounds with embryonic stem cell-derived human renal proximal tubular-like cells. Molecular Pharmaceutics link
    Special issue with featured topic: “Engineered Biomimetic Tissue Platforms for in Vitro Drug Evaluation”

  • Wang LS, Du C, Toh WS, Wan AC, Gao SJ, Kurisawa M (2014) Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatic crosslinked hydrogel with tunable mechanical properties. Biomaterials 2014; 35(7): 2207-2217  link  This article was highlighted in A*STAR Research link

  • Foldager CB, Toh WS, Olsen BR, Spector M (2014) Basement membrane molecules in normal and degenerated cartilage tissues. Cartilage 2014; 5: 123-132 link
2013
  • Cao T, Toh WS* (2013) The promise of human embryonic stem cell research in global dentistry. JSM Dentistry 1(2): 1012. (Invited Editorial)

  • Toh WS, Foldager CB, Olsen BR, Spector M (2013) Basement membrane molecule expression attendant to chondrogenic differentiation of nucleus pulposus cells and mesenchymal stem cells. Journal of Orthopaedic Research 31(7): 1136-1143. link

  • Lim TC, Rokkappanavar S, Toh WS, Wang L, Kurisawa M, Spector M (2013) Chemotactic recruitment of adult neural progenitor cells into multi-functional hydrogels providing sustained SDF-1α release and compatible structural support. FASEB J 27(3): 1023-1033. link

  • Kidwai FK, Liu H, Toh WS, Fu X, Jokhun DS, Movahednia MM, Li MM, Zou Y, Squier CA, Phan TT, Cao T (2013) Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment. Journal of Investigative Dermatology 133(3): 618-628. link
2012
  • Peng Y, Bocker MT, Holm J, Toh WS, Hughes CS, Kidwai F, Lajoie GA, Cao T, Lyko F, Raghunath M (2012) Human fibroblast matrices bio-assembled under macromolecular crowding support stable propagation of human embryonic stem cells. Journal of Tissue Engineering and Regenerative Medicine 6(10): e74-e86. link

  • Toh WS, Lim TC, Kurisawa M, Spector M (2012) Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. Biomaterials 33(15): 3835-3845. link

  • Lim TC, Toh WS, Wang L, Kurisawa M, Spector M (2012) The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. Biomaterials 33(12): 3446-3455. link
2011
  • Fu X, Toh WS, Liu H, Lu K, Li MM, Cao T (2011) Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system. Tissue Engineering Part C Methods 17(9): 927-937. link

  • Toh WS*, Spector M, Lee EH, Cao T*. (2011) Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Molecular Pharmaceutics 8(4): 994-1001. link Special issue with featured topic: “Molecular Pharmaceutical Strategies for Improved Treatment of Musculoskeletal Diseases”. (Invited) This article was reported by several media agencies worldwide.

  • Toh WS*, Lee EH, Cao T*. (2011) Potential of human embryonic stem cells in cartilage tissue engineering and regenerative medicine. Stem Cell Reviews and Reports 7(3): 544-559. link
2010
  • Toh WS, Lee EH, Guo XM, Chan JKY, Yeow CH, Choo AB, Cao T (2010) Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. Biomaterials 31(27): 6968-6980.
    link  ScienceDirect Top 25 - Biomaterials

  • Rufaihah AJ, Haider HK, Heng BC, Ye L, Tan RS, Toh WS, Tian XF, Sim EK, Cao T. (2010) Therapeutic angiogenesis by transplantation of human embryonic stem cell-derived CD133(+) endothelial progenitor cells for cardiac repair. Regenerative Medicine 5(2): 231-244. link

  • Fu X, Toh WS, Liu H, Lu K, Li MM, Hande MP, Cao T (2010) Autologous feeder cells from embryoid body outgrowth support the long-term growth of human embryonic stem cells more effectively than those from direct differentiation. Tissue Engineering Part C Methods 16(4):719-733. link
2009
  • Toh WS, Guo XM, Choo AB, Lu K, Lee EH, Cao T (2009) Differentiation and enrichment of expandable chondrogenic cells from human embryonic stem cells in vitro. Journal of Cellular and Molecular Medicine 13(9b): 3570-3590. link

  • Yang Z, Sui L, Toh WS, Lee EH, Cao T (2009) Stage-dependent effect of TGFβ1 on chondrogenic differentiation of human embryonic stem cells. Stem Cells & Development 18(6): 929-940. link

  • Liu H, Toh WS, Lu K, Macary PA, Kemeny DM, Cao T (2009) A subpopulation of mesenchymal stromal cells with high osteogenic potential. Journal of Cellular and Molecular Medicine 13(8b): 2436-2447. link
2008
  • Heng BC, Toh WS, Pereira BP, Tan BL, Fu X, Liu H, Lu K, Yeo JF, Cao T (2008) An autologous cell lysate extract from human embryonic stem cell (hESC) derived osteoblasts can enhance osteogenesis of hESC. Tissue & Cell 40(3): 219-228. link   ScienceDirect Top 25 - Tissue & Cell
2007
  • Toh WS, Yang Z, Liu H, Heng BC, Lee EH, Cao T. (2007) Effects of culture conditions and bone morphogenetic protein 2 on the extent of chondrogenesis from human embryonic stem cells. Stem Cells 25(4): 950-960. link

  • Rufaihah AJ, Haider HK, Heng BC, Ye L, Toh WS, Tian XF, Lu K, Sim EK, Cao T (2007) Directing endothelial differentiation of human embryonic stem cells via transduction with an adenoviral vector expressing VEGF165 gene. Journal of Gene Medicine 9(6): 452-461. link

  • Ye CP, Heng BC, Liu H, Toh WS, Cao T. (2007) Culture media conditioned by heat-shocked osteoblasts enhance the osteogenesis of bone marrow-derived mesenchymal stromal cells. Cell Biochemistry and Function 25(3): 267-276. link

  • Toh WS, Yang Z, Heng BC, Cao T. (2006) New perspectives in chondrogenic differentiation of stem cells for cartilage repair. ScientificWorldJournal 6: 361-364. link (Invited)
2006
  • Heng BC, Ye CP, Liu H, Toh WS, Rufaihah AJ, Cao T. (2006) Kinetics of cell death of frozen-thawed human embryonic stem cell colonies is reversibly slowed down by exposure to low temperature. Zygote 14(4): 341-348. link

  • Heng BC, Ye CP, Liu H, Toh WS, Rufaihah AJ, Yang Z, Bay BH, Ge Z, Ouyang HW, Lee EH, Cao T. (2006) Loss of viability during freeze-thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. Journal of Biomedical Science 13(3): 433-445. link
2005
  • Toh WS, Liu H, Heng BC, Rufaihah AJ, Ye CP, Cao T. (2005) Combined effects of TGFβ1 and BMP2 in serum-free chondrogenic differentiation of mesenchymal stem cells induced hyaline-like cartilage formation. Growth Factors 23(4): 313-321. link

  • Cao T, Heng BC, Ye CP, Liu H, Toh WS, Robson P, Li P, Hong YH, Stanton LW. (2005) Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures. Tissue & Cell 37(4): 325-334.
    link  ScienceDirect Top 25 - Tissue & Cell

Book Chapters

  • Toh WS* (2016) ‘Pluripotent stem cells: Differentiation potential and therapeutic efficacy for cartilage repair’ Pluripotent Stem Cells (Ed. Minoru Tomizawa) Intech Open (Invited; In press)

  • Zhang S, Wong JS, Ustunkan F, Chu WC, Tan HH, Lee EH, Toh WS* (2016) ‘Stem cells for treatment of articular cartilage defects and osteoarthritis’ Frontiers in Stem Cell and Regenerative Medicine Research 2nd Volume (Eds. Atta-Ur-Rahman and Shazia Anjum) Bentham Science (Invited; In press)

  • Parate DA^, Zhang S^, Hui JH*, Toh WS* (2015) ‘Stem cells for articular cartilage repair and regeneration’ Stem Cells in Clinical Applications (Ed. Phuc V Pham) Springer ^equal contribution (Invited; In press)

  • Yap AU*, Toh WS* (2015) ‘Repair and regeneration of temporomandibular joint: The future of stem cell-based therapies’ Stem Cells in Clinical Applications (Ed. Phuc V Pham) Springer (Invited; In press)

  • Toh WS*, Toh YC, Loh XJ* (2015) ‘Hydrogels for stem cell fate control and delivery in regenerative medicine’ Series in Bioengineering, In-situ Gelling Polymers (Ed. Xian Jun Loh) Springer (Invited; In press)

  • Toh WS*, Cao T* (2015) ‘Derivation of chondrogenic cells from human embryonic stem cells for cartilage tissue engineering. Methods in Molecular Biology, vol. 1307: , Human Embryonic Stem Cell Protocols 3rd Edition (Ed. Kursad Turksen) pp. 263-279 Humana Press (Invited; In press)

  • Toh WS, Lee EH, Richards M, Cao T. (2010) ‘In vitro derivation of chondrogenic cells from human embryonic stem cells’ Methods in Molecular Biology, vol. 584: Human Embryonic Stem Cell Protocols 2nd Edition (Ed. Kursad Turksen) pp. 317-331. Humana Press (Invited)

  • Toh WS, Yang Z, Heng BC, Cao T. (2007) ‘Differentiation of human embryonic stem cells towards the chondrogenic lineage’ Methods in Molecular Biology, vol. 407: Stem Cell Assays (Ed. Mohan C. Vemuri) pp. 333-349. Humana Press (Invited)

  • Heng BC, Toh WS, Liu H, Rufaihah AJ, Cao T. (2007) ‘Differentiation and lineage-commitment of stem cells for therapeutic applications’ Stem Cells Research Trends 1st Edition (Ed. Josse R. Braggina) pp. 117-154. Nova Press  (Invited)
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Updated: July 1, 2016