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Research Groups

Microbiology and Immunology

Overview

The Oral Microbiology and Immunology Research Group delves into the core mechanisms of oral diseases, forming the foundation for translational research to advance oral and craniofacial care.

Key Research Domains

  • Understanding the interactions between the oral microbiome and host inflammatory oral diseases that drive common oral diseases e.g. periodontal disease, oral ulcers, and oral mucositis

  • Exploring the impact of host-microbiome interactions on systemic health e.g. diabetes mellitus and cardiovascular disease
  • Developing novel diagnostic and prognostic markers for oral lesions, periodontal disease, and systemic health
  • Developing strategies to engineer symbiotic oral microbiota through probiotics, prebiotics, and novel agents

Researchers

A/P

Kai Soo TAN

Dr

Charlene Enhui GOH

Dr

Jacob Ren Jie CHEW

Publications

DOI: https://doi.org/10.1111/jcpe.14082

Prognostic Impact of Microbiome Dysbiosis: A Prospective Study

Journal of Clinical Periodontology, 2024
Authors: Ren Jie Jacob Chew, Charlene Enhui Goh, Xin Yi Sheena Lin, Feng Jun Bryan Oh, Ruiqi Paul Sim, Philip M. Preshaw, Kai Soo Tan

DOI: https://doi.org/10.1002/JPER.24-0120

Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes—An integrated data analysis

Journal of Periodontology, 2024
Authors: Ren Jie Jacob Chew, Kai Soo Tan, Tsute Chen, Nezar Noor Al-Hebshi, Charlene Enhui Goh

DOI: https://doi.org/10.1007/s00784-023-04877-8

Toll-like receptor-4 activation by subgingival biofilm and periodontal treatment response

Clinical Oral Investigations, 2023; Volume 27, 2139–2147
Authors: Ren Jie Jacob Chew, Yi Ling Tang, Xin Yi Sheena Lin, Feng Jun Bryan Oh, Ruiqi Paul Sim, Erica Jade Anwar, Philip M. Preshaw & Kai Soo Tan

DOI: https://doi.org/10.1161/JAHA.121.023038

Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS

Journal of the American Hearts Association, 2022; Volume 11, Issue 10, e023038
Authors: Charlene E. Goh, Bruno Bohn, Clarisse Marotz, Rebecca Molinsky, Sumith Roy, Bruce J. Paster, Ching‐Yuan Chen, Michael Rosenbaum, Melana Yuzefpolskaya, Paolo C. Colombo, Moïse Desvarieux, Panos N. Papapanou, DDS, David R. Jacobs Jr, Rob Knight, and Ryan T. Demmer

DOI: https://doi.org/10.1038/s41598-021-04562-4 

Oral streptococci subvert the host innate immune response through hydrogen peroxide

Scientific Reports, 2022; Volume 12, Issue 656
Authors: Yi Ling Tang, Tiow Suan Sim & Kai Soo Tan

DOI: https://doi.org/10.1038/s41598-020-66031-8 

Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects

Scientific Reports, 2020; Volume 10, Issue 9072
Authors: Yi Rong Ivan Lim, Philip M. Preshaw, Lum Peng Lim, Marianne Meng Ann Ong, Hai-Shu Lin & Kai Soo Tan

DOI: https://doi.org/10.1038/s41598-020-73292-w

Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis

Scientific Reports, 2020; Volume 10, Issue 16189
Authors: Nitasha Gupta, Joao Ferreira, Catherine Hsu Ling Hong & Kai Soo Tan