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Research Groups

Biomaterials and Tissue Engineering

Overview

The Biomaterials and Tissue Engineering Research Group focuses on advancing dental, oral, and craniofacial health through the
 development of new biomaterials, technologies, and regenerative strategies. By leveraging biomaterials, stem cells, biomolecules, 
and cutting-edge technologies, this group aims to improve health and promote the regeneration of dental, oral, and craniofacial tissues (dental pulp, bone, cartilage, gingiva, neurons, vasculature, and others).

Key Research Domains

  • Design and development of next-generation biomaterials with enhanced properties to modulate tissue response, decrease microbial colonization and improve clinical outcomes.

  • To develop advanced materials for the production of scaffolds for tissue regeneration, drug delivery systems, biosensors and technologies for diagnostics and therapies.
  • Development of exosome, biomolecular, and cellular therapeutic strategies for the regeneration of dental, oral, and craniofacial tissues with potential applications in broader medical fields.

  • Exploration of dental stem cells (e.g., pulp stem cells, periodontal ligament cells) for the regeneration of bone, soft tissue, and other complex structures in craniofacial and systemic applications.
  • Leverage 3D (bio)printing and biofabrication tools to construct patient-specific grafts and personalized solutions for craniofacial reconstruction.

  • Develop multicellular and multitypic tissue models that mimic native oral and craniofacial tissues for research on tissue interactions, disease mechanisms, and regenerative therapies.

  • Harness organ-on-chip technologies and advanced in vitro models to replicate oral tissues and their microenvironments, offering alternatives to animal testing and accelerating translational research.

Researchers

A/P

Keson Beng Choon TAN

A/P

Raymond Chung
Wen WONG

A/P

Wei Seong TOH

A/P

Vinicius ROSA

Dr

Ming Yi TAN

Dr

Sriram GOPU

Dr

Yuanyuan HAN

Publications

DOI: https://doi.org/10.1016/j.dental.2025.08.018

pH Prediction in Commercial and Experimental Calcium Silicate Cements via Material Informatics

Dental Materials, 2025, Volume 41, Issue 12, 1600-1608
Authors: Clarice Ferreira Sabino, Anastasiia Grymak, Nikolaos Silikas , Vinicius Rosa

DOI: https://doi.org/10.1016/j.bioadv.2024.214059

Achieving Biomimetic Porosity and Strength of Bone in Magnesium Scaffolds Through Binder Jet Additive Manufacturing

Biomaterials Advances, 2025, Volume 166, 214059
Authors: Mojtaba Salehi, Kai Xiang Kuah, Somasundaram Prasadh, Yuehua Li, Su Xia Zhang, Hang Li Seet, Raymond Chung Wen Wong, Mui Ling Sharon Nai

DOI: https://doi.org/10.1002/adhm.202402727

3D Bioprinting and Artificial Intelligence-assisted Biofabrication of Personalized Oral Soft Tissue Constructs

Advanced Healthcare Materials, 2025, Volume 14, Issue 13, 2402727
Authors: Yichen Dai, Peter Wang, Apurva Mishra, Kui You, Yuheng Zong, Wen Feng Lu, Edward Kai-Hua Chow, Philip M Preshaw, Dejian Huang, Jacob Ren Jie Chew, Dean Ho, Gopu Sriram

DOI: https://doi.org/10.1002/smm2.1268

Injectable Microcarrier-hydrogel Composite for Dental Stem Cell Delivery and Tissue Regeneration

SmartMat, 2024, Volume 5, Issue 5, e1268
Authors: Yu Jie Soh, Ruby Yu-Tong Lin, Gopu Sriram, Wei Seong Toh, Victoria Soo Hoon Yu, Nileshkumar Dubey

DOI: https://doi.org/10.1039/d3bm01011b

Fluid Flow-induced Modulation of Viability and Osteodifferentiation of Periodontal Ligament Stem Cell Spheroids-on-Chip

Biomaterials Science, 2023; Volume 11, Issue 22, 7432-7444
Authors: Apurva Mishra, Ren Kai, Srividya Atkuru, Yichen Dai, Filippo Piccinini, Philip M. Preshaw and Gopu Sriram

DOI: https://doi.org/10.1002/adhm.202301472


Microphysiological Modeling of Gingival Tissues and Host‐Material Interactions Using Gingiva‐on‐Chip


Advanced Healthcare Materials, 2023; Volume 12, Issue 32, 2301472
Authors: Giridharan Muniraj, Rachel Hui Shuen Tan, Yichen Dai, Ruige Wu, Massimo Alberti, Gopu Sriram

DOI: https://doi.org/10.1088/1758-5090/ace935

Modeling Periodontal Host-Microbe Interactions using Vascularized Gingival Connective Tissue Equivalents

Biofabrication, 2023, Volume 15, Issue 4, 045008
Authors: Hardik Makkar, Chwee Teck Lim, Kai Soo Tan and Gopu Sriram