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Research Groups

Biomaterials and Tissue Engineering

Overview

The Biomaterials and Tissue Engineering Research Group focuses on advancing dental, oral, and craniofacial health through the
 development of new biomaterials, technologies, and regenerative strategies. By leveraging biomaterials, stem cells, biomolecules, 
and cutting-edge technologies, this group aims to improve health and promote the regeneration of dental, oral, and craniofacial tissues (dental pulp, bone, cartilage, gingiva, neurons, vasculature, and others).

Key Research Domains

  • Design and development of next-generation biomaterials with enhanced properties to modulate tissue response, decrease microbial colonization and improve clinical outcomes.

  • To develop advanced materials for the production of scaffolds for tissue regeneration, drug delivery systems, biosensors and technologies for diagnostics and therapies.
  • Development of exosome, biomolecular, and cellular therapeutic strategies for the regeneration of dental, oral, and craniofacial tissues with potential applications in broader medical fields.

  • Exploration of dental stem cells (e.g., pulp stem cells, periodontal ligament cells) for the regeneration of bone, soft tissue, and other complex structures in craniofacial and systemic applications.
  • Leverage 3D (bio)printing and biofabrication tools to construct patient-specific grafts and personalized solutions for craniofacial reconstruction.

  • Develop multicellular and multitypic tissue models that mimic native oral and craniofacial tissues for research on tissue interactions, disease mechanisms, and regenerative therapies.

  • Harness organ-on-chip technologies and advanced in vitro models to replicate oral tissues and their microenvironments, offering alternatives to animal testing and accelerating translational research.

Researchers

A/P

Keson Beng Choon TAN

A/P

Raymond Chung
Wen WONG

A/P

Wei Seong TOH

A/P

Vinicius ROSA

Dr

Sriram GOPU

Dr

Ming Yi TAN

Publications

DOI: https://doi.org/10.1002/adhm.202301472


Microphysiological Modeling of Gingival Tissues and Host‐Material Interactions Using Gingiva‐on‐Chip


Advanced Healthcare Materials, 2023; Volume 12, Issue 32, 2301472
Authors: Giridharan Muniraj, Rachel Hui Shuen Tan, Yichen Dai, Ruige Wu, Massimo Alberti, Gopu Sriram

DOI: https://doi.org/10.1088/1758-5090/ace935

Modeling Periodontal Host-Microbe Interactions using Vascularized Gingival Connective Tissue Equivalents

Biofabrication, 2023, Volume 15, Issue 4, 045008
Authors: Hardik Makkar, Chwee Teck Lim, Kai Soo Tan and Gopu Sriram

DOI: https://doi.org/10.1039/d3bm01011b

Fluid Flow-induced Modulation of Viability and Osteodifferentiation of Periodontal Ligament Stem Cell Spheroids-on-Chip

Biomaterials Science, 2023; Volume 11, Issue 22, 7432-7444
Authors: Apurva Mishra, Ren Kai, Srividya Atkuru, Yichen Dai, Filippo Piccinini, Philip M. Preshaw and Gopu Sriram

DOI: https://doi.org/10.1002/adhm.202202376

Modeling Crevicular Fluid Flow and Host-Oral Microbiome Interactions in a Gingival Crevice-on-Chip

Advanced Healthcare Materials, 2022; Volume 12, Issue 6, 2202376
Authors: Hardik Makkar, Ying Zhou, Kai Soo Tan, Chwee Teck Lim, Gopu Sriram

DOI: https://doi.org/10.1016/j.dental.2022.06.025

Characterization of Silver Diamine Fluoride Cytotoxicity using Microfluidic Tooth-on-A-Chip and Gingival Equivalents

Dental Materials. 2022; Volume 38, Issue 8, 1385-1394
Authors: Shijia Hu, Giridharan Muniraj, Apurva Mishra , Kanglun Hong, Jing Li Lum, Catherine Hsu Ling Hong, Vinicius Rosa, Gopu Sriram